Farmlands have increasingly been exacerbated by the persistent organic pollutants (POPs), with serious consequences on food security and human health. In this study, we assessed the remediation efficiency of different control measurements on the vegetable soil contaminated by two typical POPs (DDTs and PAHs) in the greenhouse. The degradation rates of DDTs and PAHs and the activities of three kinds of soil enzymes were measured. The results showed that the treatment of rhamnolipid strengthened plant microbial remediation under the coregulation of plant growth promoting rhizobacteria and lignin had the best effect, with the degradation rates of DDTs and PAHs being 27.48% and 53.26%, respectively. At the end of experiment, polyphenol oxidase and hydrogen peroxidase were activated, with the degree of activation being higher for polyphenol oxidase than hydrogen peroxide, whereas the phosphatase activity was inhibited. Results from Pearson bivariate correlation showed that polyphenol oxidase and phosphatase activities were significantly correlated with the degradation rates of DDTs and PAHs, indicating that they can be considered as micro-ecological indicators during the remediation of POPs contaminated soil.