Abstract: The present study examined the possible protective effect of Cyanidin-3-glucoside (Cy-3-glu) against Cdinduced damage on lipids peroxidation and stress biochemical parameters of rats. SpragueDawley rats were randomly divided into 4 groups of 5 animals each and treated orally with Cd (5 mg·kg^-1),  Cy-3-glu (100 and 200 mg·kg^-1) alone or in combination for 5 days. The result showed that the treatment with Cy-3-glu obviously alleviated the body weight loss of rat caused by heavy Cd stress, and the liver, kidney and testis viscera index were significantly or extremely significantly increased with Cy-3-glu dose. Cd exposure induced significant increase in the activities of reactive oxygen species (ROS), lipid per-oxidation levels (MDA) in the exposed groups compared to the control group, and the antioxidant enzymes activities also changed, but cotreatment with Cy-3-glu (200 mg·kg^-1) significantly improved the damage induced by Cd and the SOD enzyme activities were significantly increased. The POD and CAT enzyme activities did not show concentrationresponse relationships. The antioxidant potential in liver was markedly restored with a significant decline in ROS and MDA levels. In conclusion, these results suggest that Cy-3-glu could protect the rat liver against Cd-induced injury by increasing the activities of antioxidant enzymes and reducing oxidative stress.

Key words: dissolved organic carbon, soil core, leach, adsorption.