Abstract: Due to the rapid development of industry and agriculture, a large number of environmental pollutants have been released into the environment, resulting in adverse effects such as the damage to animal organs and increasing incidence of disease. Baicalein is mainly extracted from the roots of Scutellaria baicalensis. Baicalein is a flavonoid that can play a therapeutic and restorative role in organisms through various pathways. Moreover, it can alleviate the toxic effects of pollutants. In this paper, we outlined the pharmacological functions of baicalein, such as anti-oxidative stress, anti-inflammation, anti-viral pathogens and regulation of apoptosis. The detoxification effects and mechanisms of baicalein on the intestine, heart, liver, kidney, lung, and the nervous system of animals after pollutant exposure were introduced. As a potential detoxifying and therapeutic agent, baicalein has strong detoxification effects with few side effects. Baicalein has important potential value and broad application prospects in repairing organ damage or chronic diseases caused by environmental pollutants.

Key words: environmental pollutant, baicalein, detoxification, pharmacology