Abstract: Methane (CH₄) is an important greenhouse gas with a global warming potential 34 times higher than carbon dioxide (CO₂) over a century. Wetlands are important sources of methane, contributing approximately 20%-25% of atmospheric methane. Microbially mediated methane oxidation plays a crucial role in mitigating methane emissions, particularly through the denitrifying methane anaerobic oxidation (DAMO). We reviewed the discovery, research progress and microbial mechanisms of DAMO, as well as the distribution patterns and influencing factors of DAMO relevant microorganisms in wetlands. Moreover, this review explores the inhibitory effects of methane anaerobic oxidation on methane emissions from wetlands, emphasizing its importance in ecosystems and its significance to the global climate change. This review provides valuable insights for a comprehensive understanding of the mechanism and ecological significance of methane anaerobic oxidation in wetlands, and serves as a scientific basis for wetland management and greenhouse gas mitigation.

Key words: greenhouse effect, denitrifying methane anaerobic oxidation, carbon cycle, nitrogen cycle, microbial community, functional gene