Abstract: Soil enzyme plays an important role in soil processes, which drives soil nutrient and carbon cycling by participating in the decomposition process of litter and organic matter. However, there are many factors affecting the decomposition process, including temperature and soil moisture. In this study, we examined the effects of warming, precipitation exclusion, and their combined treatment on soil extracellular enzyme activity in a mid-subtropical young Cunninghamia lanceolata plantation. These extracellular enzymes included carbonacquisition enzymes (β-glucosidase, βG; cellulose hydrolase, CBH; phenol oxidase, PHO; peroxidase, PEO), nitrogen acquisition enzyme (β-N-acetylglucosaminidase, NAG), and phosphorus acquisition enzyme (acid phosphatase, AP). The results showed that the soil moisture, microbial biomass nitrogen, dissolved organic nitrogen, and dissolved organic carbon (DOC) were significantly decreased by warming, precipitation exclusion, and their interaction. Warming significantly increased the concentrations of ammonium (NH₄⁺-N) and nitrate, and the activities of βG, CBH, and NAG (P<0.05). Precipitation exclusion enhanced the activities of βG, CBH and NAG to some extent. The activities of βG, CBH, NAG, PHO, and PEO increased slightly under the treatment of combined warming and precipitation exclusion (P>0.05). The activity of AP decreaseddramatically in all the treatments (P<0.05). Results from the redundancy analysis indicated that total nitrogen (P=0.002), NH₄⁺-N (P=0.002), and DOC (P=0.03) concentrations were the main factors driving the changes in soil enzyme activity. Our results indicated that soil enzymes involved in carbon and nitrogen cycling positively responded to warming and precipitation exclusion. Increased enzyme activities accelerated soil carbon decomposition. However, the enzyme activities involved in phosphorus cycling significantly decreased, which could induce phosphorus limitation in this ecosystem in the future. Our results have implications for better understanding of carbon and nutrient cycling under the scenarios of increasing temperature and altering precipitation.