A₃year (2009-2012) field experiment was conducted in Wuqiao County of North China Plain to study the crop yield response to different tillage modes combined with fertilization measures. Four tillage modes (rotary tillage, RT; subsoiling, ST; plough tillage, PT; no-tillage, NT) combined with three fertilization measures (manure and chemical fertilization, MF; straw returning and chemical fertilization, SF; chemical fertilization, CF) were installed, and wheat and maize were selected as test crops. Under 3year continuous tillage, the wheat yield was in the sequence of PT > ST > RT > NT, and the maize yield was in the order of RT > ST > NT > PT. When tillage was conducted in wheat season in the second year and notillage was conducted in maize season in the third year, the highest average yield of wheat and maize was observed in the treatment of sub-soiling in wheat season and in the treatment of no-tillage in maize season. When no-tillage was conducted in maize season in the second year and in wheat season in the third year, sub-soiling had the highest wheat yield, while rotary tillage had the highest maize yield. Based on the results under different tillage modes, continuous notillage for two and three years was not conducive to wheat yield improvement, and even, caused the yield decreased. However, continuous no-tillage for two and three years had less impact on maize yield, and even, could improve maize yield. As for the fertilization measures, the crop yield response in three years was consistent, and the average crop yield was in the sequence of MF > SF > CF. These results indicated that the appropriate tillage mode and fertilization measure conducive to the crop yield stability in North China Plain could be the “sub-soiling in wheat season and no-tillage in maize season combined with manure application”, under which, the crop yield could be increased by 10.6%, as compared with the widely adopted pattern (rotary tillage in wheat season and no-tillage in maize season combined with straw returning) in this area.