Abstract: Cadmium pollution in soil not only affects growth and yield formation of crop plants, but also develops a potential risk to food health. The experiment was conducted to study growth and Cd and mineral nutrient uptake of two wheat cultivars differed in agronomic performance in seedling stage under 5 Cd levels ranged from 0 to 1.0mg? kg^-1 Cd. The results showed that the growth and dry matter accumulation were stimulated in low Cd concentration (0. 03mg穔g^-1) for both cultivars, while inhibited significantly under high concentration (>0.3mg? kg^-1). The inhibited extension was dependence on cultivars and Genguo 534 had higher tolerance to Cd toxicity in comparison with E18513. There was the significant interaction between Cd level and cultivar in the influence of Cd treatment on Cd content in both root and shoot in that Genguo 534 had higher Cd content in lower Cd levels and E81513 showed more rapid increase in higher Cd levels. Cd treatment had significant influence on mineral nutrient uptake and two cultivars showed different response. In the treatment of 0. 1mg穔g^-1 Cd, the contents of five macro-nutrients were significant lower for E81513 in comparison with those in control, while Genguo remained little changed.