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西维因环境内分泌干扰效应的非受体介导作用机制研究进展

李文婷1,宋超2,吕钊1,刘颖3,冯嘉林3,陈家长1,2**   

  1. (1南京农业大学无锡渔业学院, 江苏无锡 214081; 2中国水产科学研究院淡水渔业研究中心, 江苏无锡 214081; 3无锡市动物疫病控制中心, 江苏无锡 214000)
  • 出版日期:2013-12-10 发布日期:2013-12-10

Non-receptormediated action mechanisms of endocrine disrupt effect in carbaryl environment.

LI Wen-ting1, SONG Chao2, LU Zhao1, LIU Ying3, FENG Jia-lin3, CHEN Jia-zhang1,2**   

  1. (1Wuxi Fishery College, Nanjing Agricultural University, Wuxi 214081, Jiangsu, China; 2Freshwater Fisheries Research Center, Chinese Academy of Fishery Science, Wuxi 214081, Jiangsu, China; 3Wuxi Animal Disease Prevention and Control Centre, Wuxi 214000, Jiangsu, China)
  • Online:2013-12-10 Published:2013-12-10

摘要:

西维因作为广泛使用的氨基甲酸酯类杀虫剂,不仅具有抑制乙酰胆碱酯酶活性的神经毒性,其内分泌干扰效应也备受关注。环境激素的内分泌干扰效应主要是通过对脑脑垂体性腺轴(HPG)产生作用。本文在此基础上,进一步阐述了西维因对HPG轴中性腺类固醇激素合成途径产生影响的非受体介导的内分泌干扰机制,且表现为雌激素效应。本文为深刻认识环境激素对动物的生殖、生理活动,以及理解氨基甲酸酯类杀虫剂的神经内分泌免疫行为提供了参考。
 

Abstract: As the most worldwide applied carbamates insecticide, carbaryl not only has the neurotoxic effect in inhibiting the activity of acetylcholinesterase, but also has the endocrine disrupt effect. The endocrine disrupt effect of environmental hormones is mainly produced by regulating the molecular expression of hypothalamuspituitarygonad axis (HPG). This paper further elucidated the non-receptormediated action mechanisms under the effects of carbaryl on the pathways of the steroid hormone synthesis of gonad, an important sector of HPG axis, and indicated that these non-receptor-mediated action mechanisms were the sequent results of estrogen effect. This paper would provide a reference to understand the effects of environmental hormones on the reproduction and physiology of animals, and the neuro-endocrine immune effect of carbamates insecticides.